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Sr. No. | Name of the Product | Type | CAS No. (Product) | Chemical Name | Molecular Structure |
1 | Remdesivir | API | 1809249-37-3 | N-[(S)-hydroxyphenoxyphosphinyl)-L-alanine, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile N-[(S)-hydroxyphenoxyphosphinyl)-L-alanine, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile | |
N2-Intermediate | 1191237-80-5 | (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile | |||
Intermediate 2 | 1191578-98-9 | 2-(3-((4-((Ethoxyimino)methyl)-5-(4-(trifluoromethoxy)phenyl)isoxazol-3-yl)methoxy)phenyl)acetic acid | |||
Intermediate 3 | 55094-52-5 | 2,3,5-Tri-O-benzyl-D-ribonolactone | |||
Intermediate 4 | 159326-68-8 | Pyrrolo[2,1-f][1,2,4]triazin-4-amine | |||
Intermediate 5 | 946511-97-3 | 2-Ethylbutyl L-alaninate hydrochloride (S)-2-ethylbutyl 2-aminopropanoate hydrochloride L-alanine 2-ethylbutyl ester hydrochloride | |||
Intermediate 6 | 1355049-92-1 | 2-Ethylbutyl (chloro(phenoxy)phosphoryl)-L-alaninate 2-ethylbutyl (2S)-2-(chloro(phenoxy)phosphorylamino)propanoate | |||
Intermediate 7 | 1355357-49-1 | (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile | |||
Intermediate 8 | 1191237-69-0 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (2S,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | |||
2 | Favipiravir | API | 259793-96-9 | 6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide | |
Intermediate 1 | 356783-16-9 | 3,6-Dichloropyrazine-2-carbonitrile | |||
Intermediate 2 | 55321-99-8 | 3-Hydroxypyrazine-2-carboxamide | |||
Intermediate 3 | 259793-88-9 | 5-Bromo-2-oxo-1H-pyrazine-3-carboxamide | |||
Intermediate 4 | 356783-28-3 | 3,6-Difluoropyrazine-2-carbonitrile | |||
Intermediate 5 | 356783-31-8 | 5-Fluoro-2-oxo-1H-pyrazine-3-carbonitrile 6-Fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile | |||
3 | Metoprolol | API | 98418-47-4 | butanedioic acid, compd. with 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol | |
Intermediate 1 | 56718-71-9 | 4-(2-Methoxyethyl)-phenol, p-(2-Methoxyethyl) phenol | |||
Intermediate 2 | 56718-70-8 | [[4-(2-Methoxyethyl)phenoxy]methyl]oxirane | |||
4 | Ambrisentan | API | 177036-94-1 | 2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid | |
RAC Ambrisentan Intermediate 1 | 713516-99-5 | α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic Acid | |||
Intermediate 2 | 178306-47-3 | 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester, 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester | |||
Intermediate 3 | 177036-78-1 | (S)-Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate | |||
Intermediate 4 | 1106685-61-3 | Methyl (2S)-2-[(4,6-diMethyl-2-pyriMidinyl)oxy]-3-Methoxy-3,3-diphenylpropanoate, (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate | |||
Intermediate 5 | 178306-52-0 | (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid; 2S-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid; (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid | |||
5 | Dolutegravir | API | 1051375-16-6 | (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | |
Intermediate 1 | 1246616-73-8 | (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid | |||
Intermediate 2 | 1246616-66-9 | 4-Oxo-3-(phenylmethoxy)-4H-pyran-2,5-dicarboxylic acid 2,5-dimethyl ester | |||
Intermediate 3 | 1206102-11-5 | (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | |||
Intermediate 4 | 1357289-04-3 | 2h-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid, 3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-ethylester,(4r,12as) | |||
Intermediate 5 | 61477-40-5 | (R)-3-Aminobutan-1-ol; (R)-3-Aminobutanol, (3R)-3-Amino-1-butanol | |||
Intermediate 6 | 1206102-07-9 | Methyl 3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylate, 1-(2,3-dihydroxypropyl)-1,4-dihydropy-4-oxo-3-(phenylmethoxy)-2-pyridinecarb oxylic acid methyl ester | |||
Intermediate 7 | 3775-73-7 | (R)-Homo-beta-alanine | |||
Intermediate 8 | 58610-42-7 | (R)-Homo-beta-alanine hydrochloride | |||
Intermediate 9 | 72235-52-0 | 2,4-Difluorobenzylamine | |||
Intermediate 10 | 1335210-23-5 | 1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester | |||
Intermediate 11 | 1616340-68-1 | Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate, Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate, Methyl-5-(2,4-difluorobenzylcarbaMoyl)-1-(2,2-diMethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate | |||
Intermediate 12 | 41051-15-4 | Methyl 4-methoxy-3-oxo-butanoate, Methyl 4-methoxyacetoacetate | |||
6 | Rilpivirine | API | 500287-72-9 | 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile | |
Intermediate 1 | 661489-22-1 | (Z)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile, (Z)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile | |||
Intermediate 2 | 873-74-5 | 4-Cyanoaniline; p-Cyanoaniline, 4-Aminobenzonitrile | |||
Intermediate 3 | 189956-45-4 | 4-[(1,4-Dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile, 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile | |||
Intermediate 4 | 244768-32-9 | 4-N[2(4-CHLOROPYRIMIDINYL)]-AMINO BENZONITRILE, 4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile | |||
Intermediate 5 | 661489-23-2 | (2E)-3-(4-AMino-3,5-diMethylphenyl)-2-propenenitrile Hydrochloride, (E)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride | |||
Intermediate 6 | 5637-42-3 | N-(4-Cyanophenyl)guanidine, N-(4-Cyanophenyl)guanidine | |||
Intermediate 7 | 4102-53-8 | 4-Iodo-2,6-dimethylaniline | |||
Intermediate 8 | 24596-19-8 | 4-Bromo-2,6-dimethylaniline; 4-Bromo-2,6-xylidine, 4-Bromo-2,6-dimethylaniline | |||
Intermediate 9 | 56066-83-2 | 4-Amino-3,5-Dimethyl-Benzaldehyde | |||
Intermediate 10 | 3095-47-4 | ethyl 4-aMino-3,5-diMethylbenzoate | |||
Intermediate 11 | 3993-78-0 | 2-Amino-4-chloropyrimidine | |||
7 | Ritonavir | API | 155213-67-5 | (3S,4S,6S,9S)-4-Hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-te traazatridecanoic acid 5-thiazolylmethyl ester | |
Intermediate 1 | 144163-85-9 | BDH Pure, [(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 1,1-dimethylethyl ester | |||
Intermediate 2 | 144163-97-3 | Carbonic acid 4-nitrophenyl 5-thiazolylmethyl ester, ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate | |||
Intermediate 3 | 169870-02-4 | [(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 1,1-dimethylethyl ester butanedioate, [2S,3S,5S]-2-Amino-3-hydroxy-5-tert-butyloxycarbonylamino-1,6-diphenylhexane succinate salt | |||
Intermediate 4 | 154212-61-0 | N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine; MTV-III, (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid | |||
Intermediate 5 | 183388-64-9 | BDH succinate salt, (2S,3S,5S)-5-tert-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane succinate | |||
Intermediate 6 | 162849-95-8 | (2S,3S,5S)-5-(tert-Butoxycarbonylamino)-2-(N-5-thiazolylmethoxycarbonyl)amino-1,6-diphenyl-3-hydroxyhexane, (2S,3S,5S)-5-(tert-Butoxycarbonylamino)-2-(N-5-thiazolylmethoxycarbonyl)amino-1,6-diphenyl-3-hydroxyhexane | |||
Intermediate 7 | 144164-11-4 | Thiazol-5-ylMethyl ((2S,3S,5S)-5-aMino-3-hydroxy-1,6-diphenylhexan-2-yl)carbaMate, (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane | |||
Intermediate 8 | 38585-74-9 | Thiazole-5-methanol, 5-Hydroxymethylthiazole | |||
Intermediate 9 | 156732-13-7 | (S,Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one, (S,Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | |||
Intermediate 10 | 6306-52-1 | L-2-Aminoisovaleric Acid Methyl Ester Hydrochloride | |||
Intermediate 11 | 154248-99-4 | N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine methyl ester, N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine methyl ester | |||
8 | Lopinavir | API | 192725-17-0 | (S)-N-((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide | |
Intermediate 1 | 13335-71-2 | 2,6-Dimethylphenoxyacetic acid | |||
Intermediate 2 | 156732-13-7 | (S,Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | |||
Intermediate 3 | 192725-50-1 | (2S)-(1-Tetrahydropyramid-2-one)-3-methylbutanoic acid | |||
Intermediate 4 | 192726-06-0 | N-(4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide 5-oxopyrrolidine-2-carboxylic acid | |||
Intermediate 5 | 192725-45-4 | (2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane | |||
Intermediate 6 | 51865-84-0 | N-Formyl-4-(methylamino)benzoic acid | |||
Intermediate 7 | 144163-85-9 | [(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 1,1-dimethylethyl ester | |||
Intermediate 8 | 192725-49-8 | N-[(1S,2S,4S)-4-Amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-2-(2,6-dimethylphenoxy)acetamide | |||
Intermediate 9 | 156732-12-6 | (4S)-4-(N, N-dibenzylamino)-3-oxo-5-phenylpentanonitrile | |||
9 | Darunavir | API | 206361-99-1 | [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic acid (3R,3aS,6aR)-hexahydrof uro[2,3-b]-furan-3-yl ester | |
Intermediate 1 | 501921-30-8 | (3aS,6aR)-Tetrahydro-4-methoxyfuro[3,4-b]furan-2(3H)-one | |||
Intermediate 2 | 156928-09-5 | (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol | |||
Intermediate 3 | 160232-08-6 | Tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate | |||
Intermediate 4 | 169280-56-2 | 4-Amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)benzenesulfonamide | |||
Intermediate 5 | 74124-79-1 | N,N'-Disuccinimidyl carbonate | |||
Intermediate 6 | 98737-29-2 | (2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane | |||
Intermediate 7 | 866594-60-7 | (3aS,4S,6aR)-4-methoxy-tetrahydrofuro[3,4-b]furan-2(3H)-one | |||
Intermediate 8 | 253265-97-3 | Carbonic acid 2,5-dioxo-1-pyrrolidinyl [(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl] ester | |||
Intermediate 9 | 191226-98-9 | tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate | |||
Intermediate 10 | 251105-80-3 | Benzenesulfonamide,N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-4-nitro- | |||
Intermediate 11 | 143224-62-8 | (2r,3s)-3benzyloxycarbonylami no-2-hydroxy-1-(N- | |||
Intermediate 12 | 159005-59-1 | Carbamic acid,N-[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]-, phenylmethyl ester ) | |||
Intermediate 13 | 183004-94-6 | tert-Butyl [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropyl]carbamate | |||
10 | Saxagliptin | API | 361442-04-8 | (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile | |
Intermediate 1 | 361442-00-4 | Boc-3-Hydroxy-1-adamantyl-D-glycine | |||
Intermediate 2 | 361440-67-7 | (1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester | |||
Intermediate 3 | 709031-29-8 | 3-Hydroxy-1-adamantyl-D-glycine | |||
Intermediate 4 | 709031-43-6 | N-[(1S)-2-[(1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-oxoethyl]carbamic acid 1,1-dimethylethyl ester | |||
Intermediate 5 | 866083-42-3 | (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carbonitrile | |||
Intermediate 6 | 361440-68-8 | (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide | |||
Intermediate 7 | 361440-69-9 | (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide 2,2,2-trifluoroacetate | |||
Intermediate 8 | 709031-39-0 | (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride | |||
Intermediate 9 | 709031-45-8 | (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate | |||
11 | Sitagliptin | API | 486460-32-6 | (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one | |
Intermediate 1 | 767340-03-4 | (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5- trifluorophenyl)but-2-en-2-amine | |||
Intermediate 2 | 764667-65-4 | 4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one | |||
12 | Tadalafil | API | 171596-29-5 | (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione | |
Intermediate 1 | 171489-59-1 | (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester | |||
Intermediate 2 | 14907-27-8 | D-Tryptophan methyl ester hydrochloride | |||
Intermediate 3 | 171752-68-4 | (1R,3R) – methyl-1-(benzo [d] [1,3] dioxol-5-yl) -2,3,4,9 – tetrahydro -1H –pyrido [3,4-b] indole-3-carboxylate hydrochloride |
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